Summary

Name PALB2
Full Name Partner and localizer of BRCA2
Synonyms PALB2_HUMAN | FANCN
Primary ID Q86YC2
Links - -
Type protein
Relations 5
Pathways DNA repair in cancer
Function Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656).

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Relations

Regulator Mechanism target score ℹ
+ PALB2up-regulates activity img/direct-activation.png binding BRCA1 0.845
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ DNA_damageup-regulates activity img/indirect-activation.png PALB2 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ PALB2up-regulates img/direct-activation.png binding POLH 0.513
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ PALB2up-regulates img/direct-activation.png binding BRCA2 0.941
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ PALB2up-regulates img/direct-activation.png binding RAD51 0.745
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer