Summary

Name PLD3
Full Name 5'-3' exonuclease PLD3
Synonyms Choline phosphatase 3, HindIII K4L homolog, Hu-K4, Phosphatidylcholine-hydrolyzing phospholipase D3, Phospholipase D3, PLD 3 |
Primary ID Q8IV08
Links - -
Type protein
Relations 1
Function 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation (PubMed:22428023). Plays a role in lysosomal homeostasis (PubMed:28128235). Involved in the regulation of endosomal protein sorting (PubMed:29368044).

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Relations

Regulator Mechanism target score ℹ
+ PLD3up-regulates quantity img/direct-activation.png binding APP 0.382
Publications: 1 Organism: Homo Sapiens