Summary

Name MGA
Full Name MAX gene-associated protein
Synonyms MAX dimerization protein 5 | KIAA0518, MAD5
Primary ID Q8IWI9
Links - -
Type protein
Relations 1
Function Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ MAXup-regulates activity img/direct-activation.png binding MGA 0.549
Publications: 1 Organism: Homo Sapiens