| + |
CSNK2A1 | down-regulates 
phosphorylation
|
MAX |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35768 |
Ser11 |
NDDIEVEsDEEQPRF |
Homo sapiens |
|
| pmid |
sentence |
| 8018564 |
Max activity is affected by phosphorylation at two nh2-terminal sites, ser2 and ser11. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35772 |
Ser2 |
sDNDDIEV |
Homo sapiens |
|
| pmid |
sentence |
| 8018564 |
Here, we have mapped the nh2-terminal in vivo phosphorylation sites of max to ser2 and ser11[...] |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates activity 
binding
|
MGA |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates activity
binding
|
MXD3 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates
binding
|
MYC |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8425218 |
In vivo transactivation assays suggest that myc-max and mad-max complexes have opposing functions in transcription and that max plays a central role in this network of transcription factors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
MAX | up-regulates activity
binding
|
MNT |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240354 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates activity
binding
|
MXI1 |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
The role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates activity
binding
|
MXD4 |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
MAX |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7479834 |
Mxi2 phosphorylates max both in vitro and in vivo. Phosphorylation by mxi2 may affect the ability of max to oligomerize with itself and its partners, bind dna, or regulate gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAX | up-regulates activity
binding
|
MAD1L1 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240357 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7954804 |
the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT, MXD1-4 (formerly Mad1, Mxi1, Mad3 and Mad4), and MGA. Like MYC, these proteins do not homodimerize and appear to be incapable of binding DNA on their own, but when bound to MAX, they recognize E-box sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAX
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