Summary

Name GCC2
Full Name GRIP and coiled-coil domain-containing protein 2
Synonyms 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53 | KIAA0336, RANBP2L4
Primary ID Q8IWJ2
Links - -
Type protein
Relations 3
Function Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png GCC2 0.519
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization IGF2R 0.508
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization M6PR 0.511
Publications: 1