| + |
RABEPK | up-regulates activity 
relocalization
|
M6PR |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253091 |
|
|
|
|
| pmid |
sentence |
| 9230071 |
P40 is a very potent transport factor in that the pure, recombinant protein can stimulate, significantly, an in vitro transport assay that measures transport of mannose 6-phosphate receptors from endosomes to the trans-Golgi network. The functional importance of p40 is confirmed by the finding that anti-p40 antibodies inhibit in vitro transport. Finally, p40 shows synergy with Rab9 in terms of its ability to stimulate mannose 6-phosphate receptor transport. These data are consistent with a model in which p40 and Rab9 act together to drive the process of transport vesicle docking. |
|
| Publications: |
1 |
| + |
GCC2 | up-regulates activity
relocalization
|
M6PR |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253086 |
|
|
|
|
| pmid |
sentence |
| 18195106 |
Rab9-dependent transport from late endosomes to the Golgi requires the Rab9 effectors p40 (Diaz et al., 1997) and TIP47 (Diaz and Pfeffer, 1998), a protein that recognizes the cytoplasmic domains of the two types of MPRs and packages them into nascent transport vesicles (Carroll et al., 2001). MPR recycling also utilizes a TGN-localized coiled-coil protein named GCC185 that is also a Rab9 effector |
|
| Publications: |
1 |
| + |
PLIN3 | up-regulates activity
relocalization
|
M6PR |
0.719 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253093 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 9590177 |
TIP47 is present in cytosol and on endosomes and is required for MPR transport from endosomes to the trans-Golgi network in vitro and in vivo. TIP47 recognizes a phenylalanine/tryptophan signal in the tail of the cation-dependent MPR that is essential for its proper sorting within the endosomal pathway. These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
LE-TGN SNARE | up-regulates activity
relocalization
|
M6PR |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253084 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18195106 |
These findings place the retromer complex upstream of both STX10 function and the GCC185 tethering complex in MPR transport. Together, our data suggest that STX10, STX16, Vti1a, and VAMP3 are important for the trafficking of both CD- and CI-MPRs.|Thus, MPRs must pass through a compartment of pH ≤ 5.5 before returning to the Golgi to carry out their biological function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
M6PR
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