3.0
Summary
| Name |  UBR1
|
| Full Name | E3 ubiquitin-protein ligase UBR1 |
| Synonyms | N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I |
| Primary ID | Q8IWV7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
binding