+ |
CDK1 | up-regulates activity
phosphorylation
|
RECQL4 |
0.362 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277375 |
Ser251 |
EVSIRVGsPQPSSSG |
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
29229926 |
During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK2 | up-regulates activity
phosphorylation
|
RECQL4 |
0.335 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277374 |
Ser251 |
EVSIRVGsPQPSSSG |
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
29229926 |
During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
UBR2 | up-regulates
binding
|
RECQL4 |
0.545 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-128214 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
15317757 |
The isolated recql4, assayed as a complex with ubr1 and ubr2, exhibited dna-stimulated atpase activity but was inactive as either dna helicase or dna translocase / the discovery, in the present work, that these ub ligases, ubr1 and ubr2, interact with the putative helicase recql4 (fig. 2), and that recql4 is a long-lived, non-ubiquitylated protein in hela cells |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
UBR1 | up-regulates
binding
|
RECQL4 |
0.505 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-128169 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
15317757 |
The isolated recql4, assayed as a complex with ubr1 and ubr2, exhibited dna-stimulated atpase activity but was inactive as either dna helicase or dna translocase / the discovery, in the present work, that these ub ligases, ubr1 and ubr2, interact with the putative helicase recql4 (fig. 2), and that recql4 is a long-lived, non-ubiquitylated protein in hela cells |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RECQL4 | up-regulates activity
|
DNA_repair |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258951 |
|
|
Homo sapiens |
|
pmid |
sentence |
27287744 |
RECQL4 is important for genome stability and DNA damage repair. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MCM10 | down-regulates
binding
|
RECQL4 |
0.523 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-187701 |
|
|
Homo sapiens |
|
pmid |
sentence |
19696745 |
Mcm10 inhibits recq4 helicase activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |