Summary

Name TRIM48
Full Name E3 ubiquitin-protein ligase TRIM48
Synonyms RING finger protein 101, Tripartite motif-containing protein 48 | RNF101
Primary ID Q8IWZ4
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683). This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683). TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683).

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Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination TRIM48 0.2
Publications: 1 Organism: Homo Sapiens