| + |
RPAP2 | up-regulates activity 
dephosphorylation
|
POLR2A |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248734 |
Ser1616 |
TPQSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248735 |
Ser1619 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248747 |
Ser1623 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248736 |
Ser1626 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248748 |
Ser1644 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248737 |
Ser1647 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248749 |
Ser1651 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248738 |
Ser1654 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248750 |
Ser1665 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248739 |
Ser1668 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248751 |
Ser1672 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248740 |
Ser1675 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248752 |
Ser1693 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248741 |
Ser1696 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248753 |
Ser1714 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248742 |
Ser1717 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248754 |
Ser1721 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248743 |
Ser1724 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248755 |
Ser1735 |
SPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248744 |
Ser1738 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248756 |
Ser1763 |
TPTSPSYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248745 |
Ser1766 |
SPSYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248757 |
Ser1784 |
TPTSPNYsPTSPSYS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248746 |
Ser1787 |
SPNYSPTsPSYSPTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22137580 |
In addition, we show that RPAP2 is a CTD Ser5 phosphatase. Taken together, our results indicate that during transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.|The Pol II CTD is first phosphorylated on Ser5 and then on Ser7 by CDK7. RPAP2 associates with the Pol II CTD after Ser7 phosphorylation and tethers a subcomplex of Integrator to snRNA genes. RPAP2 dephosphorylates Ser5P of the CTD, facilitating transcription and the subsequent recruitment of the Int11 catalytic subunit of Integrator |
|
| Publications: |
24 |
Organism: |
Homo Sapiens |
3.0
RPAP2
- 
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