+ |
AMPK | up-regulates quantity by stabilization
phosphorylation
|
AMOTL1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263105 |
Ser793 |
SSLRPARsVPSIAAA |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
25373897 |
we show that AMPK directly phosphorylates S793 of AMOTL1. AMPK activation stabilizes and increases AMOTL1 steady-state protein levels, contributing to YAP inhibition. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
HECW2 | up-regulates activity
ubiquitination
|
AMOTL1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278811 |
|
|
Homo sapiens |
|
pmid |
sentence |
27498087 |
These results clearly indicate that HECW2 ubiquitinates AMOTL1 with K63-linked polyubiquitin chains.|Unlike NEDD4.2, HECW2 targeted AMOTL1 and promoted its stability. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |