3.0
Summary
| Name |  IHO1
|
| Full Name | Interactor of HORMAD1 protein 1 |
| Synonyms | Cancer/testis antigen 74, CT74, Coiled-coil domain-containing protein 36 | CCDC36 |
| Primary ID | Q8IYA8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. |
ubiquitination