Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273540 |
Ser241 |
RMLSSSSsVSSLNSS |
Homo sapiens |
LNCaP Cell |
pmid |
sentence |
15998322 |
By mutagenesis analysis and subsequent immunoprecipitation (IP), we established that Akt phosphorylates JFC1 at serine 241. Phosphorylation did not alter the ability of JFC1 to bind to Rab27a. Instead, phosphorylation by Akt dramatically decreased when JFC1 was bound to Rab27a. Finally, we show that as a consequence of in vivo phosphorylation, JFC1 dissociates from the membrane, promoting JFC1 redistribution to the cytosol. |
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