Summary

Name CMTM4
Full Name CKLF-like MARVEL transmembrane domain-containing protein 4
Synonyms Chemokine-like factor superfamily member 4 | CKLFSF4
Primary ID Q8IZR5
Links - -
Type protein
Relations 1
Function Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. {ECO:0000269|PubMed:28813410}.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png stabilization CD274 0.36
Publications: 1 Organism: Homo Sapiens