Summary

Name VPS52
Full Name Vacuolar protein sorting-associated protein 52 homolog
Synonyms SAC2 suppressor of actin mutations 2-like protein | SACM2L
Primary ID Q8N1B4
Links - -
Type protein
Relations 1
Function Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).

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Relations

Regulator Mechanism target score ℹ
+ RNF41down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination VPS52 0.44
Publications: 1 Organism: Homo Sapiens