| + |
ROCK1 | up-regulates activity 
phosphorylation
|
ARHGAP24 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249309 |
Ser391 |
RSSMNNGsPTALSGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249304 |
Ser402 |
LSGSKTNsPKNSVHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249306 |
Ser413 |
SVHKLDVsRSPPLMV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249307 |
Ser415 |
HKLDVSRsPPLMVKK |
Homo sapiens |
|
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDS‚‚PAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573‚‚577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249305 |
Ser437 |
SGIVTNGsFSSSNAE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249302 |
Ser573 |
ENSNSCRsSTTTCPE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249303 |
Ser574 |
NSNSCRSsTTTCPEQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249310 |
Thr452 |
GLEKTQTtPNGSLQA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249299 |
Thr575 |
SNSCRSStTTCPEQD |
Homo sapiens |
|
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249300 |
Thr576 |
NSCRSSTtTCPEQDF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249301 |
Thr577 |
SCRSSTTtCPEQDFF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16862148 |
ROCK phosphorylates FilGAP, and this phosphorylation stimulates its RacGAP activity and is a requirement for FilGAP-mediated bleb formation. | As shown in Fig. 5b, ROCK stimulated the incorporation of phosphate into FilGAP. We identified seven potential phosphorylation sites in FilGAP that was isolated by preparative SDSPAGE and subjected to trypsin digestion and mass spectrometry: Ser 391, Ser 402, Ser 413, Ser 415, Ser 437, Thr 452, and a cluster of serine and threonine residues (SSTTT) at position 573577 (see Supplementary Information, Table S2). |
|
| Publications: |
11 |
Organism: |
Homo Sapiens |
| + |
ROCK1 | up-regulates
phosphorylation
|
ARHGAP24 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16862148 |
Rock phosphorylates filgap, and this phosphorylation stimulates its racgap activity and is a requirement for filgap-mediated bleb formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARHGAP24
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