Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248758 |
Ser337 |
TYRIGHHsTSDDSSA |
Mus musculus |
|
pmid |
sentence |
19411760 |
BCKD is inhibited by phosphorylation of its E1alpha subunit at Ser293, which is catalyzed by BCKD kinase. During BCAA excess, phosphorylated Ser293 (pSer293) becomes dephosphorylated through the concerted inhibition of BCKD kinase and the activity of an unknown intramitochondrial phosphatase. Using unbiased, proteomic approaches, we have found that a mitochondrial-targeted phosphatase, PP2Cm, specifically binds the BCKD complex and induces dephosphorylation of Ser293 in the presence of BCKD substrates |
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