3.0
Summary
| Name |  LZTR1View Modifications |
| Full Name | Leucine-zipper-like transcriptional regulator 1 |
| Synonyms | LZTR-1 | TCFL2 |
| Primary ID | Q8N653 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LZTR1 | down-regulates activity 
ubiquitination
|
KRAS | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CUL3 | up-regulates activity 
binding
|
LZTR1 | 0.277 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LZTR1 | down-regulates quantity
ubiquitination
|
KRAS | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNF | down-regulates quantity by destabilization 
|
LZTR1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |