Summary

Name GPR161
Full Name G-protein coupled receptor 161
Synonyms G-protein coupled receptor RE2 |
Primary ID Q8N6U8
Links - -
Type protein
Relations 3
Function Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization GPR161 0.593
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GNAS 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png relocalization GPR161 0.327
Publications: 1 Organism: Mus Musculus