| + |
SMO | up-regulates 
phosphorylation
|
FYN |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18455992 |
Instead, shh rapidly and locally stimulated phosphorylation of the src family kinase (sfk) members src and fyn in a smo-dependent fashion. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199156 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Instead, shh rapidly and locally stimulated phosphorylation of the src family kinase (sfk) members src and fyn in a smo-dependent fashion. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | up-regulates
phosphorylation
|
SMO |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21695114 |
We demonstrate that mammalian Smo (mSmo) is activated through multi-site phosphorylation of its carboxyl-terminal tail by CK1α and GRK2. Phosphorylation of mSmo induces its active conformation and simultaneously promotes its ciliary accumulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Fluocinonide | up-regulates activity
chemical activation
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248218 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20439738 |
We identified four FDA-approved drugs, halcinonide, fluticasone, clobetasol, and fluocinonide, as Smo agonists that activate Hedgehog signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
sonidegib | down-regulates 
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169203 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 21041712 |
Cyclopamine with improved solubility (ipi-926), smo inhibitors that considerably differ in structure from cyclopamine (gdc-0499, lde225, bms-833923, xl-139, pf-0449913), inhibitors of the transformation of inactive smo into active smo (sant 74-75), and inhibitors of the transport of cytoplasmic inactive smo to cilia (sant 1-4) have been developed to date. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174593 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 21679342 |
Cyclopamine with improved solubility (ipi-926), smo inhibitors that considerably differ in structure from cyclopamine (gdc-0499, lde225, bms-833923, xl-139, pf-0449913), inhibitors of the transformation of inactive smo into active smo (sant 74-75), and inhibitors of the transport of cytoplasmic inactive smo to cilia (sant 1-4) have been developed to date. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193630 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNAI1 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148487 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16885213 |
We found that Smo, by virtue of what appears to be constitutive activity, activates all members of the G(i) family but does not activate members of the G(s), G(q), and G(12) families. The activation is suppressed by cyclopamine and other inhibitors of Hedgehog signaling and is enhanced by the Smo agonist purmorphamine. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
GRK2 | up-regulates
phosphorylation
|
SMO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21695114 |
We find that two molecules interact with mammalian smo in an activation-dependent manner: g protein-coupled receptor kinase 2 (grk2) leads to phosphorylation of smo, and beta-arrestin 2 fused to green fluorescent protein interacts with smo. Ck1a, grk2, and another still-unidentified protein kinase phosphorylate the c-tail of mammalian smo in the presence of hh proteins |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15618519 |
We find that two molecules interact with mammalian smo in an activation-dependent manner: g protein-coupled receptor kinase 2 (grk2) leads to phosphorylation of smo, and beta-arrestin 2 fused to green fluorescent protein interacts with smo. Ck1a, grk2, and another still-unidentified protein kinase phosphorylate the c-tail of mammalian smo in the presence of hh proteins |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
We find that two molecules interact with mammalian smo in an activation-dependent manner: g protein-coupled receptor kinase 2 (grk2) leads to phosphorylation of smo, and beta-arrestin 2 fused to green fluorescent protein interacts with smo. Ck1a, grk2, and another still-unidentified protein kinase phosphorylate the c-tail of mammalian smo in the presence of hh proteins |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNG2 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148595 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199183 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
clobetasol | up-regulates activity
chemical activation
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26658258 |
Two of the top ranking compounds, Halcinonide and Clobetasol, act as Smoothened (Smo) agonists to up-regulate myelin gene expression in the Oli-neuM cell line. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248212 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20439738 |
We identified four FDA-approved drugs, halcinonide, fluticasone, clobetasol, and fluocinonide, as Smo agonists that activate Hedgehog signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
Cyclopamine | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95270 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12414725 |
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174432 |
|
|
Homo sapiens |
Medulloblastoma Cell |
| pmid |
sentence |
| 12202832 |
We investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children. Cyclopamine treatment of murine medulloblastoma cells blocked proliferation in vitro and induced changes in gene expression consistent with initiation of neuronal differentiation and loss of neuronal stem cell-like character. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Sonic Hedgehog |
| + |
SMO | up-regulates
binding
|
CXCL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
We found that smo, by virtue of what appears to be constitutive activity, activates all members of the g(i) family but does not activate members of the g(s), g(q), and g(12) families. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity 
transcriptional regulation
|
MAL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269224 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35082605 |
We show that GSA-10 promotes Gli2 upregulation, MBP and MAL/OPALIN expression via Smo/AMPactivated Protein Kinase (AMPK) signaling, and efficiently increases the number of axonal contact/ensheathment for each oligodendroglial cell. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Jervine | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139865 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 16112412 |
Here, we demonstrate that cyclopamine and jervine, two structurally related inhibitors of smo, force ciliary translocation of smo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174420 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 21679342 |
Cyclopamine (c27h41no2) and jervine (c27h39no3) were discovered and in particular, a series of studies with the hh pathway inhibitor, cyclopamine, has brought about this expectation. cyclopamine suppresses the hh signaling pathway through direct interaction with smo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
SMO | down-regulates activity 
relocalization
|
GPR161 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259937 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23332756 |
Constitutive Gpr161 activity increases cAMP levels, which is reduced upon knockdown of Gαs, suggesting it to be a Gαs-coupled receptor. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTCH1 | down-regulates activity
binding
|
SMO |
0.786 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91709 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12192414 |
We show that free Ptc (unbound by Hh) acts sub-stoichiometrically to suppress Smo activity and thus is critical in specifying the level of pathway activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14556242 |
In the responding cell, active Hedgehog binds to its receptor Patched, a 12-pass transmembrane protein, which frees Smoothened, an adjacent 7-pass transmembrane protein, for downstream signaling.Thus, a balance is created by the antagonism of Hedgehog and Patched, whose relative concentrations alternate with respect to each other. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Medulloblastoma Cell, Basal Cell Carcinoma Cell |
| Pathways: | Sonic Hedgehog |
| + |
SMO | up-regulates
binding
|
STK36 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17089004 |
Smo then activates stk36 serine/threonine kinase to stabilize gli family members and to phosphorylate sufu for nuclear accumulation of gli.| sufu binds to the kinesin cos2 to transduce the hh signal downstream of smo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity by expression
transcriptional regulation
|
TIMP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255907 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 28709001 |
We identified that ciliary Hh signaling in FAPs regulates expression of Timp3. Future experiments will determine whether Timp3 is a direct or indirect target of Hh signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMO | up-regulates
binding
|
GNB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity
transcriptional regulation
|
MBP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269226 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35082605 |
We show that GSA-10 promotes Gli2 upregulation, MBP and MAL/OPALIN expression via Smo/AMPactivated Protein Kinase (AMPK) signaling, and efficiently increases the number of axonal contact/ensheathment for each oligodendroglial cell. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMO | up-regulates activity
|
GATA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251656 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16399502 |
In mammalian models [...] Hh signaling also inhibits mammalian adipogenesis. Hh signals elicit this function early in adipogenesis, upstream of PPARγ, potentially diverting preadipocytes as well as multipotent mesenchymal prescursors away from adipogenesis and toward osteogenesis. Hh may elicit these effects by inducing the expression of antiadipogenic transcription factors such as Gata2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMO | up-regulates
binding
|
GNG3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148598 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199186 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SHH | up-regulates activity
|
SMO |
0.749 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148481 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16885213 |
Binding of Hh to Ptch relieves the repression of Smo, allowing Smo to signal. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
SMO | up-regulates
binding
|
GNAT1 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199168 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PF-5274857 | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206058 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
ARRB1 |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Grk2-mediated phosphorylation of vertebrate smo allows smo to bind to beta-arrestins 1 or 2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15618519 |
Grk2-mediated phosphorylation of vertebrate smo allows smo to bind to beta-arrestins 1 or 2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates activity
|
GATA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253527 |
|
|
|
|
| pmid |
sentence |
| 17139329 |
That GATA is a downstream effector of the hedgehog pathway. |
|
| Publications: |
1 |
| + |
SMO | up-regulates
binding
|
GNAI3 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
ARRB2 |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Grk2-mediated phosphorylation of vertebrate smo allows smo to bind to beta-arrestins 1 or 2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15618519 |
Grk2-mediated phosphorylation of vertebrate smo allows smo to bind to beta-arrestins 1 or 2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
TIAM1 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199192 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 23074268 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167070 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
SMO | up-regulates
binding
|
GNB1 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNAT2 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199171 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
vismodegib | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174417 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21679342 |
Cyclopamine with improved solubility (ipi-926), smo inhibitors that considerably differ in structure from cyclopamine (gdc-0499, lde225, bms-833923, xl-139, pf-0449913), inhibitors of the transformation of inactive smo into active smo (sant 74-75), and inhibitors of the transport of cytoplasmic inactive smo to cilia (sant 1-4) have been developed to date. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169194 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 21041712 |
Cyclopamine with improved solubility (ipi-926), smo inhibitors that considerably differ in structure from cyclopamine (gdc-0499, lde225, bms-833923, xl-139, pf-0449913), inhibitors of the transformation of inactive smo into active smo (sant 74-75), and inhibitors of the transport of cytoplasmic inactive smo to cilia (sant 1-4) have been developed to date. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates activity
binding
|
GNAI2 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
it was proposed that Smo might signal through activation of Gi proteins to reduce PKA activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148490 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16885213 |
Using this assay we determined that mouse Smo couples to all members of the Gi family but does not couple to those of other G protein families. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
SMO | up-regulates
phosphorylation
|
SRC |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18455992 |
Instead, shh rapidly and locally stimulated phosphorylation of the src family kinase (sfk) members src and fyn in a smo-dependent fashion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
fluticasone | up-regulates activity
chemical activation
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248206 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20439738 |
We identified four FDA-approved drugs, halcinonide, fluticasone, clobetasol, and fluocinonide, as Smo agonists that activate Hedgehog signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LY2940680 | down-regulates
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193805 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNG12 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152817 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity
transcriptional regulation
|
OPALIN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269225 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35082605 |
We show that GSA-10 promotes Gli2 upregulation, MBP and MAL/OPALIN expression via Smo/AMPactivated Protein Kinase (AMPK) signaling, and efficiently increases the number of axonal contact/ensheathment for each oligodendroglial cell. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMO | up-regulates activity
relocalization
|
KIF7 |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209605 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19666503 |
Here, we demonstrate that Kif7, a mammalian homologue of Drosophila Costal2 (Cos2), is a cilia-associated protein that regulates signaling from the membrane protein Smoothened (Smo) to Gli transcription factorsIn response to activation of Smo Kif7 at the cilia tip may antagonize Sufu to promote activation of Gli proteins. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
CP | down-regulates
binding
|
SMO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Genetic and biochemical studies imply that smo can adopt an active conformation but that it is normally repressed by patched (ptch), a 12-transmembrane protein considered the receptor for hh |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NME1 | down-regulates quantity by repression
transcriptional regulation
|
SMO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255168 |
|
|
Homo sapiens |
MDA-MB-435 Cell |
| pmid |
sentence |
| 17671192 |
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-338-3p | down-regulates quantity by repression
post transcriptional regulation
|
SMO |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277973 |
|
|
Homo sapiens |
MHCC97-H Cell |
| pmid |
sentence |
| 29069716 |
MiR-338-3p suppresses the invasiveness and metastasis of HCC cells by directly targeting the Smoothened (SMO) protein |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277977 |
|
|
Homo sapiens |
SW-620 Cell |
| pmid |
sentence |
| 23599646 |
MiR-338-3p, acts as a local regulator of SMO by binding to the 3’-UTR of its mRNA, thereby modulating CRC development. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-326 | down-regulates quantity by repression
post transcriptional regulation
|
SMO |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277978 |
|
|
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 25173582 |
These data indicated that miR-326 directly modulated SMO expression by binding to the 3′UTR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SGK1 | down-regulates
binding
|
SMO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25790864 |
SGK1 is known to inhibit another intrinsic pathway, the Hedgehog pathway, through downregulation of SMO and the GLI transcription factor family |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HERC4 | down-regulates quantity by destabilization
ubiquitination
|
SMO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30925584 |
Our data showed that Herc4 mediated Smo degradation by proteasome and lysosome, but mainly by proteasome.|Using the cell based ubiquitination assay, we found that both Myc-SmoK13R and Myc-SmoK49R exhibited reduced ubiquitination compared with Myc-Smo by Herc4, but Myc-SmoK49R resulted in a more dramatic reduction in Smo ubiquitination (XREF_FIG), suggesting that Smo is ubiquitinated by Herc4 at multiple Lys residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Halcinonide | up-regulates activity
chemical activation
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248265 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20439738 |
We identified four FDA-approved drugs, halcinonide, fluticasone, clobetasol, and fluocinonide, as Smo agonists that activate Hedgehog signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMO | up-regulates
binding
|
GNGT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148601 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity
transcriptional regulation
|
MAG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269227 |
|
|
|
|
| pmid |
sentence |
| 27639396 |
We found that inactivation of Shh signaling caused a dose-dependent decrease in myelin basic protein (MBP) and myelin associated glycoprotein (MAG) in differentiating OLGs. |
|
| Publications: |
1 |
| + |
purmorphamine | up-regulates
chemical activation
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154282 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
The activity of smo toward gi was stimulated severalfold with the synthetic agonist purmorphamine and inhibited almost completely by cyclopamine and other antagonists of shh. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-326 | down-regulates quantity by repression
post transcriptional regulation
|
SMO |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277979 |
|
|
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 25173582 |
The upregulation of miR-326 not only inhibited the activity of the Hh pathway but also reduced the expression of additional Hh signaling components, including GLI1, N-myc, and CyclinD1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | down-regulates activity
binding
|
SUFU |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177656 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 22114142 |
In addition to activating g(i), smo signals through its c-terminal tail to inhibit suppressor of fused, resulting in stabilization and activation of the gli family of transcription factors, which execute a transcriptional response to so-called canonical hh signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
3.0
SMO
- 
- 