3.0
Summary
| Name |  RNF152
|
| Full Name | E3 ubiquitin-protein ligase RNF152 |
| Synonyms | RING finger protein 152, RING-type E3 ubiquitin transferase RNF152 | |
| Primary ID | Q8N8N0 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). |
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polyubiquitination
ubiquitination