Summary

Name RRAGA
Full Name Ras-related GTP-binding protein A
Synonyms Rag A, RagA, Adenovirus E3 14.7 kDa-interacting protein 1, FIP-1
Primary ID Q7L523
Links - -
Type protein
Relations 4
Function Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802). Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:20381137, PubMed:24095279, PubMed:25936802). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684).

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Relations

Regulator Mechanism target score ℹ
+ RNF152down-regulates activity img/direct_inhibition.png polyubiquitination RRAGA 0.73
Publications: 1 Organism: Homo Sapiens
+ GATOR1down-regulates activity img/direct_inhibition.png gtpase-activating protein RRAGA 0.874
Publications: 1 Organism: In Vitro
+ RRAGAform complex img/form-complex.png binding RAGAC 0.77
Publications: 1 Organism: Homo Sapiens
+ RRAGAform complex img/form-complex.png binding RAGAD 0.767
Publications: 1 Organism: Homo Sapiens