3.0
Summary
| Name |  ZBTB38
|
| Full Name | Zinc finger and BTB domain-containing protein 38 |
| Synonyms | ZBT38_HUMAN | |
| Primary ID | Q8NAP3 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). |
ubiquitination