+ |
GLIS1 | up-regulates quantity by expression
transcriptional regulation
|
WNT5A |
0.25 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269040 |
|
|
Homo sapiens |
|
pmid |
sentence |
32047936 |
GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AP1 | up-regulates quantity by expression
transcriptional regulation
|
GLIS1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269041 |
|
|
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
24383088 |
Co-transfection experiments revealed that HIF-2α had greater potency on the GLIS1 promoter activation than HIF-1α. Subsequent studies using wild-type and mutant HIF-2α demonstrated that DNA binding activity was not necessary but TADs were critical for GLIS1 induction. Finally, co-transfection experiments indicated that HIF-2α cooperated with AP-1 family members in upregulating GLIS1 transcription. These results suggest that the hypoxic signaling pathway may play a pivotal role in regulating the reprogramming factor GLIS1, via non-canonical mechanisms involving partner transcription factor rather than by direct HIF transactivation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |