| Name
|
 DAGLB
|
| Full Name |
Diacylglycerol lipase-beta |
| Synonyms |
DAGL-beta, DGL-beta, KCCR13L, PUFA-specific triacylglycerol lipase, 3.1.1.3, Sn1-specific diacylglycerol lipase beta | |
| Primary ID |
Q8NCG7 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
2 |
| Function |
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). |
3.0
chemical modification
chemical modification