| + |
1,2-diacyl-sn-glycerol | up-regulates activity 
binding
|
PRKCZ |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242599 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAGLB | down-regulates quantity 
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264263 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26787883 |
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLCG1 | up-regulates
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21918248 |
Phospholypase c is an enzyme which catalyzes the hydrolysis of phosphatidylinositol-4,5-biphosphate (p(4,5)p(2)) into second messangers inositol-1,4,5-triphosphate (ins(1,4,5)p3) and dag. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation, VEGF Signaling |
| + |
1,2-diacyl-sn-glycerol | up-regulates
binding, chemical activation
|
PRKCA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18593525 |
The increases in the membrane levels of nacholeate itself and of dag induce a translocation and overexpression of protein kinase c (pkc) and subsequent reductions of cyclin d, cyclin-dependent kinases 4 and 6 (cdks 4 and 6), hypophosphorylation of the retinoblastoma protein, inhibition of e2f1 and knockdown of dihydrofolate reductase (dhfr) impairing dna synthesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23630338 |
C1a domain is critical for the dag-induced activation of pkcalfa.Furthermore, calcium and diacylglycerol activate protein kinase c, resulting in the phosphorylation of a large variety of substrates. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12954613 |
C1a domain is critical for the dag-induced activation of pkcalfa.Furthermore, calcium and diacylglycerol activate protein kinase c, resulting in the phosphorylation of a large variety of substrates. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling |
| + |
PLCG1 | up-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23140367 |
Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation, VEGF Signaling |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCE |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCQ |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242593 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAGLA | down-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26787883 |
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1,2-diacyl-sn-glycerol | up-regulates 
|
calcium(2+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18593525 |
Dag and ip3 initiate further signal transduction pathways through activation of protein kinase c (pkc) and intracellular calcium release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, Oxytocin signaling, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity
precursor of
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
PLCB1 | up-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256496 |
|
|
in vitro |
|
| pmid |
sentence |
| 23880553 |
Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second messengers diacylglycerol and inositol-1,4,5-triphosphate. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Oxytocin signaling, Thyroid Hormone Metabolism |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCI |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The molecular requirements for diacylglycerol (dag) and calcium (ca2+) to promote pkc membrane translocation, the hallmark of pkc activation, have been clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLCE1 | up-regulates
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically galfas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate many molecules, including phospholipases, ion channels and lipid kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
PLCG2 | up-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
1,2-diacyl-sn-glycerol | up-regulates activity
binding
|
PRKCA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251559 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12629049 |
Activation of PKC depends on the availability of DAG,a signaling lipid that is tightly and dynamically regulated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling |
3.0
1,2-diacyl-sn-glycerol