Summary

Name RNF169
Full Name E3 ubiquitin-protein ligase RNF169
Synonyms RING finger protein 169, RING-type E3 ubiquitin transferase RNF169 | KIAA1991
Primary ID Q8NCN4
Links - -
Type protein
Relations 1
Function Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

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Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF169 0.2
Publications: 1 Organism: Homo Sapiens