Summary

Name KREMEN2
Full Name Kremen protein 2
Synonyms Dickkopf receptor 2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose | KRM2
Primary ID Q8NCW0
Links - -
Type protein
Relations 2
Function Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.

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Relations

Regulator Mechanism target score ℹ
+ DKK1up-regulates img/direct-activation.png binding KREMEN2 0.59
Publications: 1 Organism: Homo Sapiens
+ KREMEN2down-regulates img/direct_inhibition.png binding LRP6 0.625
Publications: 1 Organism: Homo Sapiens