4.0
Summary
| Name |  FBXL13
|
| Full Name | F-box and leucine-rich repeat protein 13 |
| Synonyms | Dynein regulatory complex subunit 6, F-box/LRR-repeat protein 13 | DRC6, FBL13 |
| Primary ID | Q8NEE6 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity (PubMed:29348145). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FBXL13 | form complex 
binding
|
Nexin-dynein regulatory complex | |
| Publications: | 1 | Organism: | Homo Sapiens | |