Summary

Name DOCK8
Full Name Dedicator of cytokinesis protein 8
Synonyms DOCK8_HUMAN |
Primary ID Q8NF50
Links - -
Type protein
Relations 1
Function Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

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Relations

Regulator Mechanism target score ℹ
+ DOCK8up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.753
Publications: 1