4.0
Summary
| Name |  DOCK8
|
| Full Name | Dedicator of cytokinesis protein 8 |
| Synonyms | DOCK8_HUMAN | |
| Primary ID | Q8NF50 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). |
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guanine nucleotide exchange factor
phosphorylation