Relation Results

Summary

Name	FBH1
Full Name	F-box DNA helicase 1
Synonyms	hFBH1, EC 5.6.2.4, DNA 3'-5' helicase 1, F-box only protein 18 \| FBX18, FBXO18
Primary ID	Q8NFZ0
Links	- -
Type	protein
Relations	2
Function	3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269\|PubMed:11956208, ECO:0000269\|PubMed:17724085, ECO:0000269\|PubMed:19736316, ECO:0000269\|PubMed:23319600, ECO:0000269\|PubMed:23361013, ECO:0000269\|PubMed:25585578, ECO:0000269\|PubMed:25772361}.