Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271868 |
|
|
Mus musculus |
Macrophage |
pmid |
sentence |
30375985 |
Consistent with previous data, HDAC3 only bound to the ATP6V0E2 promoter in the presence of ALDH2.|Taken together, our data demonstrate that in the macrophages of LDLR-KO or ALDH2 rs671 mutant, AMPK phosphorylates ALDH2 at T356, which enables its nuclear translocation. Once in the nucleus, ALDH2 binds to HDAC3 and suppresses the transcription and protein expression of ATP6V0E2. |
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