Summary

Name PATJ
Full Name InaD-like protein
Synonyms Inadl protein, hINADL, Pals1-associated tight junction protein, Protein associated to tight junctions | INADL
Primary ID Q8NI35
Links - -
Type protein
Relations 1
Function Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).

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Relations

Regulator Mechanism target score ℹ
+ PATJform complex img/form-complex.png binding AMOT/MPP5/INADL/LIN7C 0.2
Publications: 1 Organism: Homo Sapiens