| + |
MPP5 | form complex 
binding
|
AMOT/MPP5/INADL/LIN7C |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203494 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24366813 |
To gain a more detailed view on the organization of this cell polarity network linked to yap1 we included several proteins of the cell junction complex (amot, mpp5, lin7a), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT/MPP5/INADL/LIN7C | up-regulates 
binding
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
Bmp7 stimulated phosphorylation of endogenous smad1 and 5, formation of complexes with smad4 and induced the promoter for the homeobox gene, tlx2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT/MPP5/INADL/LIN7C | down-regulates 
binding
|
YAP1 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170364 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21145499 |
Because we found that multiple domains of taz/yap interacted with multiple components of the crumbs complex, which include pals1, lin7c, patj, and the crumbs regulator amot, we propose that this multifactoral interaction serves to ensure that assembly of the hippo pathway and efficient phosphorylation of taz/yap is coupled only by the assembly of the crumbs complex, rather than by any single component. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates 
|
AMOT/MPP5/INADL/LIN7C |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21529719 |
In vertebrates, cell density information feeds into the Hpo pathway, which is transmitted, in part, through the Crumbs polarity complex. The Crumbs complex contains Angiomotin (AMOT), a protein that binds YAP/TAZ and SMAD to inhibit their nuclear activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
AMOT/MPP5/INADL/LIN7C | down-regulates
binding
|
WWTR1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170361 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21145499 |
Because we found that multiple domains of taz/yap interacted with multiple components of the crumbs complex, which include pals1, lin7c, patj, and the crumbs regulator amot, we propose that this multifactoral interaction serves to ensure that assembly of the hippo pathway and efficient phosphorylation of taz/yap is coupled only by the assembly of the crumbs complex, rather than by any single component. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
ACVR1 | up-regulates
phosphorylation
|
AMOT/MPP5/INADL/LIN7C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210093 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
Bmp7 stimulated phosphorylation of endogenous smad1 and 5, formation of complexes with smad4 and induced the promoter for the homeobox gene, tlx2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRB3 | up-regulates
binding
|
AMOT/MPP5/INADL/LIN7C |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170399 |
|
|
Mus musculus |
Breast Cancer Cell |
| pmid |
sentence |
| 21145499 |
Interestingly, knockdown of crb3, which facilitates crumbs complex assembly and localization to the apical junctions disrupted taz/yap interaction with multiple components of the complex, whereas the other knockdowns only disrupted their respective interaction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PATJ | form complex
binding
|
AMOT/MPP5/INADL/LIN7C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24366813 |
To gain a more detailed view on the organization of this cell polarity network linked to yap1 we included several proteins of the cell junction complex (amot, mpp5, lin7a), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LIN7C | form complex
binding
|
AMOT/MPP5/INADL/LIN7C |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24366813 |
To gain a more detailed view on the organization of this cell polarity network linked to yap1 we included several proteins of the cell junction complex (amot, mpp5, lin7a), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
AMOT/MPP5/INADL/LIN7C