+ |
NPLOC4 | up-regulates activity
binding
|
UFD1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252422 |
|
|
Homo sapiens |
|
pmid |
sentence |
20442859 |
These findings ascribe specific functions to each of the components of the VCP-UFD1L-NPL4 complex in Vpu-mediated CD4 degradation: VCP energizes the process through ATP binding and hydrolysis, UFD1L binds ubiquitinated CD4 through recognition of K48 Ub chains, and NPL4 stabilizes UFD1L. VCP is thus likely to provide the energy required for extraction of CD4 from membranes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
VCP | up-regulates activity
binding
|
NPLOC4 |
0.945 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252423 |
|
|
Homo sapiens |
|
pmid |
sentence |
20442859 |
These findings ascribe specific functions to each of the components of the VCP-UFD1L-NPL4 complex in Vpu-mediated CD4 degradation: VCP energizes the process through ATP binding and hydrolysis, UFD1L binds ubiquitinated CD4 through recognition of K48 Ub chains, and NPL4 stabilizes UFD1L. VCP is thus likely to provide the energy required for extraction of CD4 from membranes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |