Relation Results

Summary

Name RAB3IL1
Full Name Guanine nucleotide exchange factor for Rab-3A
Synonyms Rab-3A-interacting-like protein 1, Rab3A-interacting-like protein 1, Rabin3-like 1 |
Primary ID Q8TBN0
Links - -
Type protein
Relations 1
Function Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP t ...
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Type: Score: Layout: SPV 
0.274Elongator complexRAB3IL1

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Relations
Regulator
Mechanism
target
score ℹ
+ Elongator complexup-regulates activity img/direct-activation.png binding RAB3IL1 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-269714 in vitro
pmid sentence
Our results raise the possibility that regulation of polarized exocytosis is an evolutionarily conserved function of the entire Elongator complex and that FD results from a dysregulation of neuronal exocytosis. Our results raise the possibility that regulation of polarized exocytosis is an evolutionarily conserved function of the entire Elongator complex and that FD results from a dysregulation of neuronal exocytosis. We show that elp1Δ suppression of sec2ts is not a result of reduced transcriptional elongation and that Elp1p physically associates with Sec2p. The Sec2p interaction domain of Elp1p is necessary for both Elp1p function and for the polarized localization of Sec2p. Mutations in human Elp1p (IKAP) are a known cause of familial dysautonomia (FD).
Publications: 1 Organism: In Vitro
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