3.0
Summary
| Name |  MARCHF1View Modifications |
| Full Name | E3 ubiquitin-protein ligase MARCHF1 |
| Synonyms | Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171, RING-type E3 ubiquitin transferase MARCHF1 | MARCH1, RNF171 |
| Primary ID | Q8TCQ1 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MARCHF1 | down-regulates quantity by destabilization 
polyubiquitination
|
HLA-DRA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF1 | down-regulates quantity by destabilization
polyubiquitination
|
HLA-DRB4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARCHF1 | down-regulates quantity by destabilization
polyubiquitination
|
HLA-DRB3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
MARCHF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |