3.0
Summary
| Name |  CD86
|
| Full Name | T-lymphocyte activation antigen CD86 |
| Synonyms | Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1 | CD28LG2 |
| Primary ID | P42081 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). |
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transcriptional regulation