3.0
Summary
| Name |  HCAR2
|
| Full Name | Hydroxycarboxylic acid receptor 2 |
| Synonyms | G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor | GPR109A, HCA2, HM74A, NIACR1 |
| Primary ID | Q8TDS4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | bis(2-ethylhexyl) phthalate | up-regulates activity 
chemical activation
|
HCAR2 | 0.8 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |