+ |
diisononyl phthalate | up-regulates activity
chemical activation
|
OXER1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268773 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
pmid |
sentence |
27551952 |
We discovered that di(2-ethylhexyl) phthalate (DEHP) and di-isononyl phthalate (DiNP), two of the highest volume production agents, were potent activators of human CAR2 (hCAR2), a unique human CAR splice variant and, to a lesser degree, human PXR (hPXR). |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
monoisononyl phthalate | up-regulates activity
chemical activation
|
OXER1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268778 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
pmid |
sentence |
27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
mono(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
OXER1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268776 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
pmid |
sentence |
27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |