| + |
MRGPRD | down-regulates 
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262309 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23446738 |
Alamandine produces several physiological actions that resemble those produced by angiotensin-(1-7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that alamandine acts through the Mas-related G-protein-coupled receptor, member D. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | SARS-CoV FIBROSIS |
| + |
Alamandine | up-regulates activity 
binding
|
MRGPRD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262308 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 23446738 |
Alamandine produces several physiological actions that resemble those produced by angiotensin-(1-7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that alamandine acts through the Mas-related G-protein-coupled receptor, member D. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Pathways: | SARS-CoV FIBROSIS |
| + |
MRGPRD | down-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262310 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 30918468 |
Our data suggested that both Ang-(1-7) and alamandine, through their respective receptors Mas and MrgD, promote an anti-inflammatory reprogramming of M(LPS+IFN-γ)/M1 macrophages under inflammatory circumstances and potentiate the reprogramming induced by IL-4. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | SARS-CoV FIBROSIS |
3.0
MRGPRD
- 
- 