| + |
Alamandine | up-regulates activity 
binding
|
MRGPRD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262308 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 23446738 |
Alamandine produces several physiological actions that resemble those produced by angiotensin-(1-7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that alamandine acts through the Mas-related G-protein-coupled receptor, member D. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Pathways: | SARS-CoV FIBROSIS |
| + |
MRGPRD | up-regulates activity
binding
|
GNAI1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281549 |
|
|
Homo sapiens |
HOSE Cell |
| pmid |
sentence |
| 33886554 |
Using this threshold G protein coupling was detected for 22 of the 48 receptors and 48 of the 240 pairings in our sample (Fig 3; S1 File). We detected constitutive coupling of 18 receptors to Gi1, 8 receptors to Gs, 6 receptors to Gq, 7 receptors to G13, and 9 receptors to G15. Of the 22 profiled receptors 11 are annotated for G protein coupling in the IUPHAR Guide to Pharmacology (GtoPdb), and within this set there was excellent agreement between our results and annotated coupling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRGPRD | up-regulates activity
binding
|
GNAQ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281550 |
|
|
Homo sapiens |
HOSE-A Cell |
| pmid |
sentence |
| 33886554 |
Using this threshold G protein coupling was detected for 22 of the 48 receptors and 48 of the 240 pairings in our sample (Fig 3; S1 File). We detected constitutive coupling of 18 receptors to Gi1, 8 receptors to Gs, 6 receptors to Gq, 7 receptors to G13, and 9 receptors to G15. Of the 22 profiled receptors 11 are annotated for G protein coupling in the IUPHAR Guide to Pharmacology (GtoPdb), and within this set there was excellent agreement between our results and annotated coupling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRGPRD | up-regulates activity
binding
|
GNA15 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281551 |
|
|
Homo sapiens |
HOSE-B Cell |
| pmid |
sentence |
| 33886554 |
Using this threshold G protein coupling was detected for 22 of the 48 receptors and 48 of the 240 pairings in our sample (Fig 3; S1 File). We detected constitutive coupling of 18 receptors to Gi1, 8 receptors to Gs, 6 receptors to Gq, 7 receptors to G13, and 9 receptors to G15. Of the 22 profiled receptors 11 are annotated for G protein coupling in the IUPHAR Guide to Pharmacology (GtoPdb), and within this set there was excellent agreement between our results and annotated coupling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRGPRD | up-regulates activity
binding
|
GNA13 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281552 |
|
|
Homo sapiens |
INER-37 Cell |
| pmid |
sentence |
| 33886554 |
Using this threshold G protein coupling was detected for 22 of the 48 receptors and 48 of the 240 pairings in our sample (Fig 3; S1 File). We detected constitutive coupling of 18 receptors to Gi1, 8 receptors to Gs, 6 receptors to Gq, 7 receptors to G13, and 9 receptors to G15. Of the 22 profiled receptors 11 are annotated for G protein coupling in the IUPHAR Guide to Pharmacology (GtoPdb), and within this set there was excellent agreement between our results and annotated coupling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRGPRD | down-regulates 
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262310 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 30918468 |
Our data suggested that both Ang-(1-7) and alamandine, through their respective receptors Mas and MrgD, promote an anti-inflammatory reprogramming of M(LPS+IFN-γ)/M1 macrophages under inflammatory circumstances and potentiate the reprogramming induced by IL-4. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | SARS-CoV FIBROSIS |
| + |
MRGPRD | down-regulates
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262309 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23446738 |
Alamandine produces several physiological actions that resemble those produced by angiotensin-(1-7), including vasodilation, antifibrosis, antihypertensive, and central effects. Interestingly, our data reveal that its actions are independent of the known vasodilator receptors of the RAS, Mas, and angiotensin II type 2 receptor. Rather, we demonstrate that alamandine acts through the Mas-related G-protein-coupled receptor, member D. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | SARS-CoV FIBROSIS |
4.0
MRGPRD
- 
- 