Summary

Name STYX
Full Name Serine/threonine/tyrosine-interacting protein
Synonyms Protein tyrosine phosphatase-like protein |
Primary ID Q8WUJ0
Links - -
Type protein
Relations 1
Function Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding FBXW7 0.353
Publications: 1 Organism: Homo Sapiens