| + |
Kindlin | up-regulates activity 
binding
|
FBLIM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269956 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBLIM1 | up-regulates activity
binding
|
FLNB |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266106 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FERMT1 | up-regulates activity
binding
|
FBLIM1 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266103 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FERMT2 | up-regulates activity
binding
|
FBLIM1 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266108 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26037143 |
Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we demonstrate that Kindlin-2-Y193 phosphorylation regulates Kindlin-2-mediated cell spreading and migration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266102 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
FBLIM1 | up-regulates activity
binding
|
FLNA |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266105 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBLIM1 | up-regulates activity
binding
|
FLNC |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266107 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FERMT3 | up-regulates activity
binding
|
FBLIM1 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266104 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
FBLIM1
- 
- 