Summary

Name ARAP3
Full Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Synonyms Centaurin-delta-3, Cnt-d3 | CENTD3
Primary ID Q8WWN8
Links - -
Type protein
Relations 2
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.496
Publications: 1 Organism: Homo Sapiens