Relation Results

Summary

Name SOCS4
Full Name Suppressor of cytokine signaling 4
Synonyms SOCS-4, Suppressor of cytokine signaling 7, SOCS-7 | SOCS7
Primary ID Q8WXH5
Links - -
Type protein
Relations 2
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of ...
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Type: Score: Layout: SPV 
0.20.496SOCS4DAB1CUL5

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by destabilization img/direct_inhibition.png binding DAB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272139 Chlorocebus aethiops COS-7 Cell
pmid sentence
SOCS7 promotes Dab1 polyubiquitylation and degradation. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. SOCS7, a CRL5 substrate adaptor protein, is also required for neocortical layering. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1.
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding CUL5 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-272141 Chlorocebus aethiops COS-7 Cell
pmid sentence
SOCS7 promotes Dab1 polyubiquitylation and degradation. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. SOCS7, a CRL5 substrate adaptor protein, is also required for neocortical layering. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1.
Publications: 1 Organism: Chlorocebus Aethiops
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