Relation Results

Summary

Name NCSTN
Full Name Nicastrin
Synonyms NICA_HUMAN | KIAA0253
Primary ID Q92542
Links - -
Type protein
Relations 11
Pathways Alzheimer
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such ...
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Type: Score: Layout: SPV 
0.3390.9650.9410.9680.9680.9410.965SGK1NCSTNPSEN1PSEN2APH1AAPH1Bgamma-secretase

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SGK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NCSTN 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-276415 Ser437 FLRARNIsGVVLADH Homo sapiens HEK-293 Cell
pmid sentence
SGK1 directly bound to and phosphorylated NCT on Ser437, thereby promoting protein degradation.
Publications: 1 Organism: Homo Sapiens
+ NCSTNup-regulates img/direct-activation.png binding PSEN1 0.965
Identifier Residue Sequence Organism Cell Line
SIGNOR-98724 Homo sapiens
pmid sentence
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-96253 Homo sapiens
pmid sentence
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-118852 Homo sapiens
pmid sentence
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2.
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Alzheimer
+ NCSTNup-regulates img/direct-activation.png binding PSEN2 0.941
Identifier Residue Sequence Organism Cell Line
SIGNOR-81936 Homo sapiens
pmid sentence
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2.
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ NCSTNup-regulates img/direct-activation.png binding APH1A 0.968
Identifier Residue Sequence Organism Cell Line
SIGNOR-96250 Homo sapiens
pmid sentence
We show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. Similar to the loss of presenilin or nicastrin, the inactivation of endogenous maph-1 using small interfering rnas results in the decrease of presenilin levels, accumulation of gamma-secretase substrates (app carboxyl-terminal fragments), and reduction of gamma-secretase products (amyloid-beta peptides and the intracellular domains of app and notch).
Identifier Residue Sequence Organism Cell Line
SIGNOR-103611 Homo sapiens
pmid sentence
We show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. Similar to the loss of presenilin or nicastrin, the inactivation of endogenous maph-1 using small interfering rnas results in the decrease of presenilin levels, accumulation of gamma-secretase substrates (app carboxyl-terminal fragments), and reduction of gamma-secretase products (amyloid-beta peptides and the intracellular domains of app and notch).
Identifier Residue Sequence Organism Cell Line
SIGNOR-93313 Homo sapiens
pmid sentence
We show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. Similar to the loss of presenilin or nicastrin, the inactivation of endogenous maph-1 using small interfering rnas results in the decrease of presenilin levels, accumulation of gamma-secretase substrates (app carboxyl-terminal fragments), and reduction of gamma-secretase products (amyloid-beta peptides and the intracellular domains of app and notch).
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ APH1Aup-regulates img/direct-activation.png binding NCSTN 0.968
Identifier Residue Sequence Organism Cell Line
SIGNOR-93259 Homo sapiens
pmid sentence
By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ APH1Bup-regulates img/direct-activation.png binding NCSTN 0.941
Identifier Residue Sequence Organism Cell Line
SIGNOR-93307 Homo sapiens
pmid sentence
By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain.These data indicate that maph-1 is probably a functional component of the gamma-secretase complex
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ NCSTNform complex img/form-complex.png binding gamma-secretase 0.965
Identifier Residue Sequence Organism Cell Line
SIGNOR-209711 Homo sapiens
pmid sentence
-Secretase is a four subunit, 19-pass transmembrane enzymeBiochemical studies indicated that -secretase activity is catalyzed by the presenilin (PS)-containing macromolecular complex (Li et al., 2000a). The search for other components of the complex revealed three additional proteins: nicastrin (Nct), anterior pharynx-defective-1 (Aph-1), and presenilin enhancer-2 (Pen-2)
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
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