Relation Results

Summary

Name	PSEN2 View Modifications
Full Name	Presenilin-2
Synonyms	PS-2, AD3LP, AD5, E5-1, STM-2 \| AD4, PS2, PSNL2, STM2
Primary ID	P49810
Links	- -
Type	protein
Relations	29
Pathways	Alzheimer
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).

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▶Modifications Tables

PSEN2 as Target

Residue

Sequence

Modifier

Effect

Modification

Asp326

YDPEMEEdSYDSFGE

CASP1	activation	cleavage
CASP3	activation	cleavage
CASP7	activation	cleavage
CASP6	activation	cleavage
CASP8	activation	cleavage

Asp329

EMEEDSYdSFGEPSY

CASP1	activation	cleavage
CASP3	activation	cleavage
CASP7	activation	cleavage
CASP6	activation	cleavage
CASP8	activation	cleavage

Ser19

EVCDERTsLMSAESP

CSNK1A1	unknown	phosphorylation
CSNK1D	unknown	phosphorylation
CSNK2A1	unknown	phosphorylation

Ser327

DPEMEEDsYDSFGEP

CSNK1D	activation	phosphorylation
CSNK2A1	activation	phosphorylation

Ser330

MEEDSYDsFGEPSYP

CSNK1D	activation	phosphorylation
CSNK2A1	activation	phosphorylation

Ser335

YDSFGEPsYPEVFEP

CSNK1D	activation	phosphorylation
CSNK2A1	activation	phosphorylation

Ser7

sDSEEEVC

CSNK1A1	unknown	phosphorylation
CSNK1D	unknown	phosphorylation
CSNK2A1	unknown	phosphorylation

Ser9

LTFMASDsEEEVCDE

CSNK1A1	unknown	phosphorylation
CSNK1D	unknown	phosphorylation
CSNK2A1	unknown	phosphorylation

Relations

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Regulator

Mechanism

target

score ℹ

CASP1

up-regulates activity img/direct-activation.png

cleavage