Summary

Name FIG4
Full Name Polyphosphoinositide phosphatase
Synonyms Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3 | KIAA0274, SAC3
Primary ID Q92562
Links - -
Type protein
Relations 4
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding PAS complex 0.929
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding FIG4 0.919
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity img/direct_inhibition.png chemical modification 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)(5-) 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png MCOLN1 0.367
Publications: 1 Organism: Homo Sapiens