+ |
FIG4 | down-regulates quantity
chemical modification
|
1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)(5-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253535 |
|
|
in vitro |
|
pmid |
sentence |
23165282 |
Fig4/Sac3 can decrease PI(3,5)P2 levels via its phosphatase function and also promote PI3,5P2 synthesis by acting as a secondary scaffold for the Fab1/Vac14 interaction. However, the later function appears dominant. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
FIG4 | form complex
binding
|
PAS complex |
0.929 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253528 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17556371 |
Here we have identified and characterized Sac3, a Sac domain phosphatase, as the Fig4 mammalian counterpart. Endogenous Sac3, a widespread 97-kDa protein, formed a stable ternary complex with ArPIKfyve and PIKfyve. Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FIG4 | up-regulates activity
|
MCOLN1 |
0.363 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253536 |
|
|
Homo sapiens |
|
pmid |
sentence |
23165282 |
PI(3,5)P2 begins to be synthesized on endosomal membranes and is additionally required for the activation of lysosomal TRPML1/MCOLN1 channels. Thus, a deficiency of FIG4/PI(3,5)P2 would impair TRPML1/MCOLN1 channel function, leading to the accumulation of calcium in the lysosomes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
VAC14 | up-regulates quantity by stabilization
binding
|
FIG4 |
0.919 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253534 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
20630877 |
Our data indentify a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J. our data are consistent with the notion that when associated with ArPIKfyve, Sac3 is stabilized and protected from degradation, whereas in the absence of associated ArPIKfyve, Sac3 remains unfolded and, hence, prone to rapid destruction. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |